In most mail clients, the setup is limited to specifying mail servers and mailbox access details.
For example, if you have yourdomain.com, the settings would look like this:
A server for receiving mail:
mail.yourdomain.com – a server for receiving mail via POP3 or IMAP
Port for receiving mail via POP3: 110, for POP3 via SSL: 995
Port for receiving mail via IMAP: 143, for IMAP via SSL: 993
A server for sending mail:
smtp.yourdomain.com – server for sending mail
Port for sending via SMTP: 587 (we recommend this port, since port 25 is often blocked by ISPs, and for sending via SSL: 465)
Also in the mail client is necessary to enable SMTP authentication, otherwise sending mail will not work correctly.
Note: instead of yourdomain.com – substitute your domain.